Monday, April 15, 2013

Vitamin D may reduce risk of uterine fibroids

Apr. 15, 2013 ? Women who had sufficient amounts of vitamin D were 32 percent less likely to develop fibroids than women with insufficient vitamin D, according to a study from researchers at the National Institutes of Health.

Fibroids, also known as uterine leiomyomata, are noncancerous tumors of the uterus. Fibroids often result in pain and bleeding in premenopausal women, and are the leading cause of hysterectomy in the United States.

The study of 1,036 women, aged 35-49, living in the Washington, D.C., area from 1996 to 1999, was led by Donna Baird, Ph.D., a researcher at the National Institute of Environmental Health Sciences (NIEHS), part of NIH. Baird and her collaborators at The George Washington University and the Medical University of South Carolina screened participants for fibroids using ultrasound. They used blood samples to measure the primary circulating form of vitamin D, known as 25-hydroxy D. Those with more than 20 nanograms per milliliter of 25-hydroxy D were categorized as sufficient, though some experts think even higher levels may be required for good health. The body can make vitamin D when the skin is exposed to the sun, or vitamin D can come from food and supplements.

Study participants also completed a questionnaire on sun exposure. Those who reported spending more than one hour outside per day also had a decreased risk of fibroids. The estimated reduction was 40 percent. Although fewer black than white participants had sufficient 25-hydroxy D levels, the estimated reduction in prevalence of fibroids was about the same for both ethnic groups.

"It would be wonderful if something as simple and inexpensive as getting some natural sunshine on their skin each day could help women reduce their chance of getting fibroids," said Baird.

Baird also noted that, though the findings are consistent with laboratory studies, more studies in women are needed. Baird is currently conducting a study in Detroit to see if the findings from the Washington, D.C., study can be replicated.

Other NIEHS in-house researchers, led by Darlene Dixon, D.V.M., Ph.D., are learning more about fibroid development, by examining tissue samples from study participants who had surgery for fibroids.

"This study adds to a growing body of literature showing the benefits of vitamin D," said Linda Birnbaum, Ph.D., director of NIEHS and the National Toxicology Program.

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The above story is reprinted from materials provided by National Institute of Environmental Health Sciences (NIEHS).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Baird DD, Hill MC, Schectman JM, Hollis BW. Vitamin D and the risk of uterine fibroids. Epidemiology, 2013

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/nutrition/~3/oOZ-w-WON6Y/130415094453.htm

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Nanosponges soak up toxins released by bacterial infections and venom

Monday, April 15, 2013

Engineers at the University of California, San Diego have invented a "nanosponge" capable of safely removing a broad class of dangerous toxins from the bloodstream ? including toxins produced by MRSA, E. coli, poisonous snakes and bees. These nanosponges, which thus far have been studied in mice, can neutralize "pore-forming toxins," which destroy cells by poking holes in their cell membranes. Unlike other anti-toxin platforms that need to be custom synthesized for individual toxin type, the nanosponges can absorb different pore-forming toxins regardless of their molecular structures. In a study against alpha-haemolysin toxin from MRSA, pre-innoculation with nanosponges enabled 89 percent of mice to survive lethal doses.

Administering nanosponges after the lethal dose led to 44 percent survival.

The team, led by nanoengineers at the UC San Diego Jacobs School of Engineering, published the findings in Nature Nanotechnology April 14.

"This is a new way to remove toxins from the bloodstream," said Liangfang Zhang, a nanoengineering professor at the UC San Diego Jacobs School of Engineering and the senior author on the study. "Instead of creating specific treatments for individual toxins, we are developing a platform that can neutralize toxins caused by a wide range of pathogens, including MRSA and other antibiotic resistant bacteria," said Zhang. The work could also lead to non-species-specific therapies for venomous snake bites and bee stings, which would make it more likely that health care providers or at-risk individuals will have life-saving treatments available when they need them most.

The researchers are aiming to translate this work into approved therapies. "One of the first applications we are aiming for would be an anti-virulence treatment for MRSA. That's why we studied one of the most virulent toxins from MRSA in our experiments," said "Jack" Che-Ming Hu, the first author on the paper. Hu, now a post-doctoral researcher in Zhang's lab, earned his Ph.D. in bioengineering from UC San Diego in 2011.

Aspects of this work will be presented April 18 at Research Expo, the annual graduate student research and networking event of the UC San Diego Jacobs School of Engineering.

Nanosponges as Decoys

In order to evade the immune system and remain in circulation in the bloodstream, the nanosponges are wrapped in red blood cell membranes. This red blood cell cloaking technology was developed in Liangfang Zhang's lab at UC San Diego. The researchers previously demonstrated that nanoparticles disguised as red blood cells could be used to deliver cancer-fighting drugs directly to a tumor. Zhang also has a faculty appointment at the UC San Diego Moores Cancer Center.


Engineers at the University of California, San Diego have invented a ?nanosponge? capable of safely removing a broad class of dangerous toxins from the bloodstream -- including toxins produced by MRSA, E. coli, poisonous snakes and bees. These nanosponges, which thus far have been studied in mice, can neutralize ?pore-forming toxins,? which destroy cells by poking holes in their cell membranes. Unlike other anti-toxin platforms that need to be custom synthesized for individual toxin type, the nanosponges can absorb different pore-forming toxins regardless of their molecular structures. In a study against alpha-haemolysin toxin from MRSA, pre-innoculation with nanosponges enabled 89 percent of mice to survive lethal doses. Administering nanosponges after the lethal dose led to 44 percent survival. Credit: UC San Diego Jacobs School of Engineering

Red blood cells are one of the primary targets of pore-forming toxins. When a group of toxins all puncture the same cell, forming a pore, uncontrolled ions rush in and the cell dies.

The nanosponges look like red blood cells, and therefore serve as red blood cell decoys that collect the toxins. The nanosponges absorb damaging toxins and divert them away from their cellular targets. The nanosponges had a half-life of 40 hours in the researchers' experiments in mice. Eventually the liver safely metabolized both the nanosponges and the sequestered toxins, with the liver incurring no discernible damage.

Each nanosponge has a diameter of approximately 85 nanometers and is made of a biocompatible polymer core wrapped in segments of red blood cells membranes.

Zhang's team separates the red blood cells from a small sample of blood using a centrifuge and then puts the cells into a solution that causes them to swell and burst, releasing hemoglobin and leaving RBC skins behind. The skins are then mixed with the ball-shaped nanoparticles until they are coated with a red blood cell membrane.

Just one red blood cell membrane can make thousands of nanosponges, which are 3,000 times smaller than a red blood cell. With a single dose, this army of nanosponges floods the blood stream, outnumbering red blood cells and intercepting toxins.

Based on test-tube experiments, the number of toxins each nanosponge could absorb depended on the toxin. For example, approximately 85 alpha-haemolysin toxin produced by MRSA, 30 stretpolysin-O toxins and 850 melittin monomoers, which are part of bee venom.

In mice, administering nanosponges and alpha-haemolysin toxin simultaneously at a toxin-to-nanosponge ratio of 70:1 neutralized the toxins and caused no discernible damage.

One next step, the researchers say, is to pursue clinical trials.

###

University of California - San Diego: http://www.ucsd.edu

Thanks to University of California - San Diego for this article.

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Source: http://www.labspaces.net/127740/Nanosponges_soak_up_toxins_released_by_bacterial_infections_and_venom

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Icy therapy spot treats cancer in the lung

Apr. 14, 2013 ? Frozen balls of ice can safely kill cancerous tumors that have spread to the lungs, according to the first prospective multicenter trial of cryoablation. The results are being presented at the Society of Interventional Radiology's 38th Annual Scientific Meeting in New Orleans.

"Cryoablation has potential as a treatment for cancer that has spread to the lungs from other parts of the body and could prolong the lives of patients who are running out of options," said David A. Woodrum, M.D., Ph.D., an author of the study and interventional radiologist at the Mayo Clinic in Rochester, Minn. "We may not be able to cure the cancer, but with cryoablation we can at least slow it down significantly and allow patients to enjoy greater quality of life longer," he added. Metastatic lung disease is difficult to treat and often signals a poor prognosis for patients.

In the initial results of the study, called the ECLIPSE trial (Evaluating Cryoablation of Metastatic Lung/Pleura Tumors in Patients -- Safety and Efficacy), 22 subjects with a total of 36 tumors were treated with 27 cryoablation sessions. Cryoablation was 100 percent effective in killing those tumors at three-month follow-up. Follow-up at six months on 5 of the 22 patients (23 percent) showed the treated tumors to still be dead. Cryoablation is performed by an interventional radiologist using a small needle-like probe guided through a nick in the skin to cancerous tumors inside the lung under medical imaging guidance. These tumors have spread -- or metastasized -- to the lung from primary cancers in other areas of the body. Once in position, the tip of the instrument is cooled with gas to as low as minus 100 degrees Celsius. The resulting halo of ice crystals can destroy cancer by interrupting its cellular function, protecting nearby healthy, delicate lung tissue. Lung cryoablation has been promising in part due to the low periprocedural morbidity.

"Most of these patients can go home the day after their cryoablation treatment and resume their normal activities," Woodrum said, noting that researchers plan to continue to follow patients for up to five years. While cryoablation is being developed for the treatment of metastatic lung cancer, the future looks brighter for individuals who once had nowhere else to turn, said Woodrum, who was assisted in research by Frank Nichols, M.D. and Matthew R. Callstrom, M.D.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/VPMV3U_0EvY/130414121146.htm

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Woman dead, search suspended for man missing in Washington avalanches

NBC News

Sheriff's department at scene of avalanche.

By Craig Giammona, NBC News

One woman has now been declared dead while a 60-year-old man is still missing after a pair of avalanches? ripped through the mountains Saturday near Snoqualmie Pass in Washington state, authorities said.

The search for the missing man was suspended indefinitely Saturday night because of poor weather in the area, located about 50 miles east of Seattle, the King Country Sheriff's office said.


Authorities said three men hiking to the summit of Granite Mountain, near exit 47 on I-90, were swept away in an avalanche that hit a little before 1 p.m. Saturday. NBC station KING in Seattle said the avalanche carried the men about 1,000 feet. Two of the three hikers were able to get free from the snow, but the third member of their group, a 60-year-old man, was not located and remains missing.

Snoqualmie Pass, located along I-90, is a popular skiing and snowshoeing destination.

In a separate incident Saturday afternoon, a woman died after being buried under five feet of snow when an avalanche hit near exit 52 off I-90. The incident occurred not long after the first avalanche in the area, authorities said.

A group of hikers snowshoeing in the area was caught in the avalanche Saturday. The members of that group were able to "self rescue," but realized the woman, who was walking nearby, was missing, officials said.

The group found the woman 45 minutes later buried in the snow and dug her out.

Authorities said the woman was "not moving and somewhat conscious" was she was rescued. Rescuers hiked for two hours to reach the woman and brought her out of the wilderness on a sled, authorities said. Medics eventually declared the woman dead.

The mountains in the area have been hit by spring snow in recent days, with a ski area at Snoqualmie Pass reporting 11 inches of new snow.

The Northwest Weather and Avalanche Center reported considerable avalanche danger above 3,000 feet Sunday. Westbound lanes of the Interstate-90 highway over the pass were closed Saturday night because of heavy snow.

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2ab4f7ac/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A40C140C177481140Ewoman0Edead0Esearch0Esuspended0Efor0Eman0Emissing0Ein0Ewashington0Eavalanches0Dlite/story01.htm

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Sunday, April 14, 2013

Close vote seen on background checks on gun buyers

Sen. Joe Manchin, D-W.Va., becomes emotional as he meets in his office with families of victims of the Sandy Hook Elementary School shooting in Newtown, Conn., on the day he announced that they have reached reached a bipartisan deal on expanding background checks to more gun buyers, at the Capitol in Washington, Wednesday, April 10, 2013. (AP Photo/J. Scott Applewhite)

Sen. Joe Manchin, D-W.Va., becomes emotional as he meets in his office with families of victims of the Sandy Hook Elementary School shooting in Newtown, Conn., on the day he announced that they have reached reached a bipartisan deal on expanding background checks to more gun buyers, at the Capitol in Washington, Wednesday, April 10, 2013. (AP Photo/J. Scott Applewhite)

Sen. Joe Manchin, D-W.Va., left, meets in his office with families of victims of the Sandy Hook Elementary School shooting in Newtown, Conn., on the day he announced that he reached a bipartisan deal on expanding background checks to more gun buyers, at the Capitol in Washington, Wednesday, April 10, 2013. From left are Manchin, Nelba Marquez-Greene, mother of victim Ana Marquez-Greene, and Mark and Jackie Barden, parents of victim Daniel Barden. (AP Photo/J. Scott Applewhite)

WASHINGTON (AP) ? A bipartisan Senate proposal to expand background checks for gun buyers gained the backing of one Republican and the potential support of a second Sunday as sponsors said the vote expected this week was too close to call.

The plan would "strengthen the background check system without in any way infringing on Second Amendment rights," Maine Sen. Susan Collins said in a statement explaining her support for the measure. But she added that "it is impossible to predict at this point" what will be in a final bill.

Arizona Sen. John McCain, who has a B+ rating from the National Rifle Association, said he was "very favorably disposed" to the proposal that has emerged from Sens. Patrick Toomey, R-Pa., and Joe Manchin, D-W.Va.

"I appreciate their work," McCain said. "And the American people want to do what we can to prevent these tragedies. And there's a lot more that needs to be done, particularly in the area of mental health."

It was in McCain's home state that a gunman with schizophrenia shot then-Rep. Gabrielle Giffords in the head during a 2011 rampage in Tucson that left six people killed.

Collins and Sen. Mark Kirk of Illinois are the only two Republicans besides Toomey who are expected to vote for the compromise as of now.

It will take 60 votes to pass, meaning that more Republicans will have to come on board because some Democrats from gun-friendly states are expected to oppose the measure.

"It's an open question as to whether or not we have the votes. I think it's going to be close," Toomey said.

The measure requires background checks for people buying guns at gun shows and online. Background checks currently apply only to transactions handled by the country's 55,000 licensed gun dealers. Private transactions, such as a sale of a gun between family members, would still be exempt.

Manchin urged lawmakers to read the 49-page proposal. He said it should dispel any misconceptions about infringing on the constitutional right to bear arms.

"You can imagine for what, the last two or three months, that all you heard is they're going to take this away from you and that away," and all of the gun groups are trying to outdo each other, Manchin said Sunday on Fox News Channel. "And the bottom line is when you have a group now ? Alan Gottlieb, the chairman of the Citizens Committee for the Right to Keep and Bear Arms, said, 'We read the bill, we like the bill' and it protects law-abiding gun owners like myself. And they are supporting it now. That is huge."

Gottlieb did not respond to a request Sunday to provide more details of the position taken by his group.

The senators' agreement actually includes language expanding firearms rights by easing some restrictions on transporting guns across state lines, protecting sellers from lawsuits if buyers passed a check but later used a gun in a crime and letting gun dealers conduct business in states where they don't live.

"If you are a law-abiding gun owner, you're going to like this bill," Manchin said.

He acknowledged the vote would be tight. Asked how many votes he thought he had now, Manchin said: "Well, we're close. We need more."

The compromise, if successful, would be added to broader gun control legislation to strengthen laws against illegal gun trafficking and to increase slightly school security aid.

Other additions to the legislation also are expected to be debated this week, including a measure that would allow concealed hand gun permits issued by one state to be accepted nationwide as a de facto background check.

Sen. Marco Rubio, R-Fla., said in news show interviews that concealed weapons permits should be applied nationally. He also called for more prosecution of people that are trying to buy guns and fail a background check.

The Senate is also expected to consider, and reject, Democratic amendments to ban assault weapons and ammunition magazines carrying more than 10 rounds.

Manchin and Toomey were on CNN's "State of the Union" and CBS' "Face the Nation." McCain was on CNN.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-14-Gun%20Control/id-a09813eecaaf4d1aa9cd9b969161ebb5

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Excerpts From Laurene Powell Jobs' First Interview Since The Death Of Steve Jobs

Laurene_Powell_JobsIn the first interview since her husband’s death, Laurene Powell Jobs dedicated her sizable platform to advancing immigration reform, while remaining notably tight-lipped about the private life of the late Steve Jobs. We’ve included highlights (with context) from her interview with Rock Center host, Brian Williams. On Steve Jobs: “Pretty Cool” Legacy BRIAN WILLIAMS: It’s another way of saying we’re left with a world of really cool stuff. I always wanted to know what it was like to be a Kennedy and drive to Kennedy Airport; and what it’s like to be you at a light and watch ten people cross, and the only thing they have in common are white ear buds. What’s that like? LAURENE POWELL JOBS: It’s pretty cool. BRIAN WILLIAMS: (LAUGHS) It’s pretty cool. I mean, that changed our world. LAURENE POWELL JOBS: Yeah. To do what you wanna do, to leave a mark– in a way that you think is important and lasting, that’s a life well lived. On Immigration Reform Powell Jobs has been a vocal advocate of immigration reform, partnering with director Davis Guggenheim (Waiting For Superman, An Inconvenient Truth) on a documentary highlighting the struggles of talented, patriotic American youth who have been denied entrance into the military and college, because they are undocumented immigrants. To add public pressure for Congress to pass a bill that provides a pathway to citizenship for children of immigrants who came to America illegally, the film (trailer below) is accompanied by a grassroots campaign and website. BRIAN WILLIAMS: Climb into the minds of our viewers watching you guys on Friday night. So help us process this. How are we supposed to feel about their parents, who did do something bad? This is ill-gotten gains, because the first entry into this country was wrong. How are we supposed to feel about the bureaucracy we would now have to have just to hand Social Security numbers to our Marine, our civil engineer? LAURENE JOBS POWELL: Yes. It’s understandable that people are conflicted about this. And, yes, the parents broke the law. And so I think that’s why Congress is trying to find a way to make amends. So have them pay a penalty, have them pay back taxes. Have them wait for two decades in order to have the chance to have citizenship. I mean, there are penalties that can be brought out. But then you have someone

Source: http://feedproxy.google.com/~r/Techcrunch/~3/qtI-kckGb4w/

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'Harry Potter' Quidditch World Cup begins in Florida

KISSIMMEE, Fla. (AP) ? Who says "Harry Potter" is just for the pages of books and movies?

Thanks to the brainchild of two college roommates eight years ago, the International Quidditch Association is staging its sixth World Cup event in Kissimmee beginning on Saturday, and bringing 80 worldwide teams to compete in a real-life version of the sport played by characters in the fictional series.

Other than not having the ability to fly on broomsticks, quidditch has grown from a grassroots fringe activity enjoyed by "Harry Potter" fans to one that both novices and diehards alike can enjoy.

Although he embraces the growth, the league's commissioner, Alex Benepe, says he is resisting the urge to take on sponsorships in hopes of keeping the sport's original community spirit intact.

Source: http://news.yahoo.com/harry-potter-sport-stages-world-cup-florida-202944619.html

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